Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted Hepatocyte Growth Factor MET Activator Rescues Working Memory Deficits after Repeated Mild Traumatic Brain Injury Katelyn A. Martino, Arush Nakhre, Renee M. Demarest, David M. Devilbiss, 2025 Structure and biologic function of HGF: HGF c MET signaling pathways Download Scientific Diagram Small Molecule AngIV based Analogs to Treat Alzheimers Disease Molecular mechanism(s) of regulation(s) of c MET HGF signaling in head and neck cancer Molecular Cancer Springer Nature Link The Role of HGF c Met Pathway Signaling in Human Medulloblastoma IntechOpen
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dihexa hgf c-met agonist What is dihexa, its mechanism of action via the HGF/c-Met pathway, and its safety and clinical use?