Acetaminophen toxicity EMCrit Project Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen toxicity EMCrit Project Acetaminophen Overdose Concise Medical Knowledge Acetaminophen Toxicity in Children: Diagnosis, Clinical Assessment, and Treatment of Acute Overingestion Consultant360 Paracetamol toxicity Deranged Physiology