Does Ibuprofen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA The Truth About Paracetamol and Glutathione Levels Is Acetaminophen or Ibuprofen better for kids? THE PEDIATRICIAN MOM Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism of acetaminophen and Taking Tylenol? The Glutathione Connection Dr. Green Mom Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.