Glutathione Cell Defense Integrative Therapeutics Glutathione: pharmacological aspects and implications for clinical use Geriatric Care Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Mast Cell Activation Syndrome and Its Impact on the Lymphatics How Mycotoxins Trigger Mast Cell Activation and Brain Inflammation Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione.