Dapagliflozin attenuates cisplatin induced nephrotoxicity in rats through modulation of ROS NF B, BCL2 Bax and PINK1 Parkin signaling pathways Scientific Reports For CKD, I'd separate the proven support from the experimental but interesting category. Astragalus root extract is probably the most tried and true natural compound I'd look at first. There's actual human data showing Chronic Kidney Disease: Stages, Treatments & Nutrition Hacks Life Extension N Acetylcysteine Mitigates Renal Fibrosis by Modulating Inflammasome and Gluconeogenic Pathways Under Cardiometabolic Stress Is creatine dangerous? Does it cause liver or kidney damage? Vitamin C is not recommended for individuals with only one kidney Dr Ibrahim Osman, Ceo, Nature blend hospital #mylawyermycounselor