Your blood tests are normal. Your sleep is adequate. You're still exhausted. This is the most common presentation I see in clinic and the answer is almost never found on a Methylation cycle hypothesis MEpedia When people think about detox, they usually think about the liver. But detoxification actually involves several systems working together. One of the most important is methylation. Methylation supports processes involved in Methyl donor supplementation reduces phosphoTau, Fyn and demethylated protein phosphatase 2A levels and mitigates learning and motor deficits in a mouse model of tauopathy Hummel 2023 Neuropathology and Applied Effects of Altered Maternal Folic Acid, Vitamin B12 and Docosahexaenoic Acid on Placental Global DNA Methylation Patterns in Wistar Rats PLOS One Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation: Cell Metabolism