Glutathione Does Ibuprofen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA What To Avoid When Taking Glutathione Which analgesic causes liver toxicity? Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Does Ibuprofen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA