Machine learning guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis: Cell Metabolism Combined metabolic activators to treat mitochondrial dysfunction Mitochondrial dysfunction is a common feature of many human diseases and is emerging as a therapeutic target. Systems biology and multiomics approaches have revealed that Carnitine transport and fatty acid oxidation ScienceDirect L Carnitine and Acylcarnitines: Mitochondrial Biomarkers for Precision Medicine Dysfunction of the carnitine cycle in tumor progression ScienceDirect The Role of l Carnitine in Mitochondria, Prevention of Metabolic Inflexibility and Disease Initiation