Role of glutathione in oxidative stress. During oxidative stress there Download Scientific Diagram Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Frontiers Glutathione deficiency in the pathogenesis of SARS CoV 2 infection and its effects upon the host immune response in severe COVID 19 disease AZD5904 Research The Mathias Laboratory Department of Nutritional Sciences University of Connecticut Mast Cell Activation Syndrome (MCAS) Dr. Todd Maderis