Acetaminophen metabolism Tylenol uses up the liver's stores of GLUTATHIONE. Glutathione is the body's most important ANTIOXIDANT. Acetaminophen Use During Pregnancy and Autism Risk Researchers are studying a possible link between acetaminophen (Tylenol) use during pregnancy and higher autism or ADHD risk. It may lower glutathione, an important antioxidant for brain development. Tylenol & Glutathione What Parents Need to Know! , I get it, many parents are concerned about giving their child Tylenol (acetaminophen) because it can lower glutathione, a crucial antioxidant that Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect