Metabolism of Paracetamol (Acetaminophen), Acetanilide and Phenacetin Medicinal Chemistry PharmaXChange.info Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. An Example of a Drug That Causes Toxicity Through the Formation of a Chemically Reactive Intermediate Mechanisms of Adverse Drug Reactions Pharmacovigilance NAPQI Wikipedia Kantify Improving Human Health through Artificial Intelligence Tylenol's Impact on Glutathione and Liver Damage