Feeling worse before you feel better? It might be a Herx. Also called a Jarisch Herxheimer reaction, herxing happens when Lyme microbes are killed off and release toxins into your system, sparking a Tumor targeted glutathione oxidation catalysis with ruthenium nanoreactors against hypoxic osteosarcoma Nature Communications Detoxing While Treating Lyme Disease Project Lyme L Glutathione reduced (GSH) Antioxidant MedChemExpress Shortness of Breath in Lyme Disease: What to Know Daniel Cameron MD Lyme disease and tick borne diseases are complicated illnesses and because of that, treatment can be complex. Patients who've gone through treatment will often say your symptoms get worse before they get better.