Acetaminophen Anesthesia Key Sex differences in glutathione metabolism and acetaminophen toxicity Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen Glutathione Disodium Salt CAS 64889 81 2 (free acid) SCBT Santa Cruz Biotechnology Sex differences in glutathione metabolism and acetaminophen toxicity Acetaminophen, also known as Tylenol, is used to help with pain & to reduce fever. However, taking too much acetaminophen can be harmful to the liver which filters out toxins &