Frontiers Paracetamol Induced Glutathione Consumption: Is There a Link With Severe COVID 19 Illness? Acetaminophen Depletes Glutathione Essential Formulas Heres why you should avoid Tylenol , First of all, it is full of colorful dyes, sugars, and additives., But the main reason is it depletes glutathione., Glutathione is one of the most Acetaminophen or Tylenol Toxicity Lect 19 Pharmacology Best Glutathione Supplement: What's Your Best Option? GoodRx Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.