Short Note On Carnitine Shuttle: Fatty acids are oxidized in mitochondria, and synthesized in the cytoplasm. Long chain fatty acids must form an active intermediate, fatty acyl CoA, before being oxidized inside mitochondria. Catherine Frontiers Carnitine Traffic in Cells. Link With Cancer Clinical Biochemistry department College of medicine AL Mustansiriyah University Dr. Ali al bayati Lipid metabolism The Biomics Carnitine shuttle system for transporting fatty acyl CoA into the mitochondrial matrix. The path of the acyl group is traced in red. #biochemistry #biochem #biochimica #biochimie #bioquimica #biochemie #biolchem # Carnitine shuttle system and beta oxidation of fatty acids L carnitine is primarily synthesized in the liver from the amino acids lysine and methionine through a series of four enzymatic reactions, with the liver and kidneys converting the precursor butyrobetaine into active