Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Tylenol And Glutathione Invigor Medical Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Tylenol's Impact on Glutathione and Liver Damage PDF] Evidence that Increased Acetaminophen use in Genetically Vulnerable Children Appears to be a Major Cause of the Epidemics of Autism, Attention Deficit with Hyperactivity, and Asthma Semantic Scholar Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine