Vitamin B12 induced acneiform eruption: Heliyon Is B12 making you break out? It's possible. We've found in our own experience and in clinical studies that certain forms of vitamin B12 can trigger inflammatory acne for some individuals. Can Vitamin b12 Injections Cause Nasty Rashes? Vitamin B12 and Acne Breakouts from Vitamin B12 are some of the most common I see, even in longtime clients who are using excellent skin products and otherwise have their acne under control. , B12 causes inflamed acne and Can B12 Vitamins Cause Acne? Evidence and Management Bolt Pharmacy