Did you know that B12 supplements can significantly contribute to acne? , Ive seen it time and time again with my clientsmany experience stubborn breakouts that clear up once they stop Breakouts from Vitamin B12 are some of the most common I see, even in longtime clients who are using excellent skin products and otherwise have their acne under control. , B12 causes inflamed acne and Cortisone Shots for Acne: How They Work and Their Benefits GoodRx vitamin b12 GAVE me acne skin care journey #1 Vitamin B12 study hints at a molecular mechanism for acne pathogenesis The Pharmaceutical Journal Is B12 making you break out? It's possible. We've found in our own experience and in clinical studies that certain forms of vitamin B12 can trigger inflammatory acne for some individuals.