Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Mast Cell Activation Syndrome Mast Cell Activation Syndrome: The Hidden Culprit Behind Mysterious Multi System Symptoms Dr. Jill Carnahan, MD Mast Cell Activation Syndrome Levitas Clinic Guildford IRE1 determines ferroptosis sensitivity through regulation of glutathione synthesis Nature Communications Ways to Address Perinatal Mast Cell Activation and Focal Brain Inflammation, including Response to SARS CoV 2, in Autism Spectrum Disorder