BPC 157 Erectile Dysfunction: Exploring the Peptide Research and Real World Considerations BPC 157 and Penis Growth: What the Evidence Shows and What It Doesn't Can BPC 157 Cause Erectile Dysfunction? Phosphodiesterase type 5 (PDE5) inhibitors are medications used to treat erectile dysfunction (ED) and pulmonary hypertension. They include sildenafil, vardenafil, tadalafil, and avanafil. These medications inhibit the PDE5 enzyme in endothelial cells, BPC 157 Weight Loss: Evidence & Safety There are zero randomized clinical trials on BPC 157. Zero. Here's what we actually know: it was isolated from stomach acid because researchers noticed those cells regenerate constantly in a harsh environment.