New Insights into Melanocytes Beyond Conventional Recognition Encyclopedia MDPI Labial melanotic macule Despite the name "melanosis," the pigment isn't melanin. The Pigment: It is actually lipofuscin, a "wear and tear" pigment. The Process: Anthraquinone laxatives cause apoptosis (cell death) of the colonic epithelial cells. Feline Iris Hyperpigmentation MSPCA Angell Oral melanotic macula on the lower labial vestibular mucosa on a Download Scientific Diagram Happy Wednesday! , In this video, a patients labial melanotic macule (a benign pigmented lesion) is being treated with liquid nitrogen. Labial melanotic macules are flat and asymmetrical with a