Glutathione deficiency can lead to a variety of signs and symptoms that affect your overall health. Here are some common signs to look out for: 1. **Increased Dark Spots** Glutathione Glutathione: What It Is, Why You Need It, How You Can Increase It The Amino Company Cognitive Function In Depth Linus Pauling Institute Oregon State University Glutathione synthetase deficiency MedLink Neurology Glutathione reductase deficiency causes symptoms and treatment options Infinite Labs Glutathione synthetase deficiency MedLink Neurology