A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential ScienceDirect Pharmacology 401 k Paracetamol NAPQI Glutathione COX3 Poisoning Antidote AcetylCysteine Frontiers Acetaminophen induced liver injury: Molecular mechanism and treatments from natural products Combination of Paracetamol and the Glutathione Depleting Agent Buthionine Sulfoximine Show Differential Effect on Liver Cancer Cells and Normal Hepatocytes Paracetamol is one of the most commonly used analgesic and antipyretic drugs.
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paracetamol and glutathione depletion The gamma-glutamyl pathway after glutathione depletion due to