Neurocutaneous Melanosis (Neurocutaneous melanocytosis) Dermatology Advisor This lovely patient was thrilled with her beautiful result after laser treatment of oral melanotic macules. I share this case to educate: laser treatment requires accurate diagnosis, an understanding of the differential Iris Melanosis in Cats: Causes, Symptoms, and Treatment Cats.com Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Melanosis coli: Symptoms, causes, treatment, and more Conjunctival Melanoma: Symptoms & Treatment