What Vitamins Should Not Be Taken Together? BodyBio GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Paracetamol (acetaminophen) toxicity occurs when the liver is overwhelmed by a toxic metabolite called N acetyl p benzoquinone imine (NAPQI), which is normally detoxified by glutathione. In overdose, glutathione is depleted, and NAPQI accumulates, leading Paracetamol (also known as acetaminophen) is primarily metabolized in the liver through two main pathways: Phase I metabolism Phase II metabolism. In Phase I metabolism, paracetamol is Dr.ibad Khan GLUTACAN 600MG INJECTION (Glutathione), For Skin Whitening, Packaging Type: Pack at 480 vial in Nagpur Management of paracetamol poisoning