Understanding and Managing Glucose 6 Phosphate Dehydrogenase Deficiency ScienceDirect Glucose 6 phosphate dehydrogenase deficiency Knowledge @ AMBOSS G6PD Deficiency causes Haemolytic Anaemia Glucose 6 phosphate dehydrogenase is an enzyme in the hexose monophosphate shunt that synthesizes NADPH. The NADPH is used to convert oxidized glutathione (GSSG) to reduced glutathione ( pharmacology Anti malarial drugs and g6pd deficiency Biology Stack Exchange Pathology of G6PD deficiency Pathology Made Simple Hepatic Glucose 6 Phosphate Dehydrogenase (G6PD) plays a pivotal role in the Pentose Phosphate Pathway, generating NADPH for antioxidant defense and supporting nucleotide & amino acid biosynthesis.