How can I minimize liver damage while taking Tylenol (acetaminophen) in relation to glutathione levels? Glutathione, Alcohol and drugs Since Tylenol is such a hot topic right now, did you know it depletes glutathione levels? When your body processes Tylenol in the liver, one of the pathways creates a toxic byproduct. To neutralize g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram When Good Drugs Go Bad: Acetaminophen Toxicity tl;dr pharmacy A Possible Antidote for Tylenol (Paracetamol) Overdose American Council on Science and Health