Pigmented Oral Lesions: Clues to Identifying the Potentially Malignant Consultant360 Lip melanotic macula Hoogstra Medical Centers Mystery behind labial and oral melanotic macules: Clinical, dermoscopic and pathological aspects of Laugier Hunziker syndrome Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Differential Diagnosis of Pigmented Lesions in the Oral Mucosa: A Clinical Based Overview and Narrative Review What Caused These Multiple Hyperpigmented Macules of the Mouth?