Tylenol's Impact on Glutathione and Liver Damage Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg kg intravenous acetaminophen in very preterm infants Pediatric Research GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY PDF) Erratum to: The effects of acute acetaminophen toxicity on hepatic mRNA expression of SOD, CAT, GSH Px, and levels of peroxynitrite, nitric oxide, reduced glutathione, and malondialdehyde in rabbit Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S transferase Pi PNAS Ferroptosis and intrinsic drug induced liver injury by acetaminophen and other drugs: a critical evaluation and historical perspective EurekAlert!