Please hear my heart here! There's no judgment from me, but this info is important and definitely not something widely talked about! It is very common advice parents receive to just give Acetaminophen induces liver injury and depletes glutathione in mice brain: Prevention by Moringa oleifera extract ScienceDirect g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Is Tylenol Safe During Pregnancy? Risk Factors, Not Causation Acetaminophen metabolism Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.