Unveiling the molecular basis of paracetamol induced hepatotoxicity: Interaction of N acetyl p benzoquinone imine with mitochondrial succinate dehydrogenase ScienceDirect The gamma glutamyl pathway after glutathione depletion due to Download Scientific Diagram Reducing the effects of drug toxicity on glutathione metabolism ScienceDirect A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Paracetamol toxicity Deranged Physiology