Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic Glutathione DepletionInduced Activation of Dimersomes for Potentiating the Ferroptosis and Immunotherapy of Cold Tumor Zhou 2022 Angewandte Chemie International Edition Wiley Online Library Full article: The central role of glutathione in the pathophysiology of human diseases Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells Cell Death & Disease Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells Cell Death & Disease Glutathione Depletion and Stalwart Anticancer Activity of Metallotherapeutics Inducing Programmed Cell Death: Opening a New Window for Cancer Therapy ACS Omega