Tylenol: How much is too much of a good thing? Allied Medical Training Figure 1: CMAJ Tylenol And Glutathione Invigor Medical Understanding the Impact of Acetaminophen: Tylenol and Glutathione in Autism Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen's Role in Autism and ADHD: A Mitochondrial Perspective