Is Blood Donation Good for Health? Dr. Karuna Kumar Can You Donate Blood or Plasma if You Use Cannabis? YES, you can donate blood if you smoke or consume cannabis. Let's break the stigma! All donors go through the same health screening. All blood donations are tested for several types Myth: You can't donate blood if you smoke or drink. Fact: Smoking or occasional drinking doesn't automatically disqualify you. But avoid alcohol for at least 24 hours before donating to Teen Vaping: What Parents Can Do Children's Hospital Colorado Smoking (or vaping) doesn't affect your ability to donate blood. Help us bust this myth by sharing our post.