g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Taking Tylenol? The Glutathione Connection Dr. Green Mom Dr. Tylenol (acetaminophen) is not something I use or give my children or recommend for pregnant women. It depletes glutathione, an extremely important antioxidant and detoxification agent in the human body. Paracetamol (Acetaminophen) hepatotoxicity and its management. Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Acetaminophen metabolism